Dr Nolan Hoffman

Postdoctoral Research Fellow

Dr Nolan Hoffman

Exercise and Nutrition Research Program

Areas of expertise: Metabolism, exercise, nutrition, skeletal muscle physiology, type 2 diabetes, insulin resistance, signal transduction, signalling networks, cellular energy sensing, AMP-activated protein kinase, glycogen, insulin action, glucose transporter GLUT4, human physiology, rodent physiology, cell biology, molecular biology, proteomics, phosphoproteomics

ORCID ID: 0000-0001-5168-7082

Phone: +61 3 9230 8277

Email: nolan.hoffman@acu.edu.au

Location: ACU Melbourne Campus

Dr Nolan Hoffman is a Postdoctoral Research Fellow at Australian Catholic University (ACU) based at the Mary MacKillop Institute for Health Research in Melbourne, Australia. Nolan earned his BSc (Honours) in Biology at Butler University in 2007 and his PhD in Cellular and Integrative Physiology from Indiana University in 2012 in his hometown of Indianapolis, Indiana USA. He was named the Chancellor’s Scholar in 2012 as the top student in the Graduate School’s Doctoral Program and also received postgraduate training in the Business of Life Sciences at Indiana University Kelley School of Business. Nolan completed his postdoctoral research from 2012 to 2016 in Sydney, Australia at the Garvan Institute of Medical Research and University of Sydney. He was awarded the 2015 Australian Physiological Society’s Postdoctoral Research Publication Prize for research that uncovered the exercise-regulated signalling network in human skeletal muscle. Commencing his position at ACU in 2016, Nolan currently leads the Integrative Physiology Group within the Exercise and Nutrition Research Program and is regularly invited to speak at local, national and international scientific seminar series and conferences. Nolan’s multidisciplinary research involves molecular, cellular, biochemical, proteomic and physiological approaches aimed at identifying novel mechanisms by which exercise and nutrition influence metabolic health and disease. Within this scope, his research group utilises cellular, animal and human model systems to map and interrogate signaling networks and energy-sensing pathways such as AMP-activated protein kinase (AMPK) underlying whole-body and skeletal muscle metabolic homeostasis.

Download CV (PDF, 113KB)

Select publications

  • Janzen, N. R., Whitfield, J., & Hoffman, N. J. (2018). Interactive Roles for AMPK and Glycogen from Cellular Energy Sensing to Exercise Metabolism. Int J Mol Sci, 19(11). doi:10.3390/ijms19113344
  • Leckey, J. J., Hoffman, N. J., Parr, E. B., Devlin, B. L., Trewin, A. J., Stepto, N. K., . . . Hawley, J. A. (2018). High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans. FASEB J, 32(6), 2979-2991. doi:10.1096/fj.201700993R
  • Hoffman, N. J. (2017). Omics and Exercise: Global Approaches for Mapping Exercise Biological Networks. Cold Spring Harb Perspect Med, 7(10). doi:10.1101/cshperspect.a029884
  • Lee-Young, R. S., Hoffman, N. J., Murphy, K. T., Henstridge, D. C., Samocha-Bonet, D., Siebel, A. L., . . . Febbraio, M. A. (2016). Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle. Mol Metab, 5(11), 1083-1091. doi:10.1016/j.molmet.2016.09.002
  • Hoffman, N. J., Parker, B. L., Chaudhuri, R., Fisher-Wellman, K. H., Kleinert, M., Humphrey, S. J., . . . James, D. E. (2015). Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates. Cell Metab, 22(5), 922-935. doi:10.1016/j.cmet.2015.09.001
  • Stockli, J., Meoli, C. C., Hoffman, N. J., Fazakerley, D. J., Pant, H., Cleasby, M. E., . . . James, D. E. (2015). The RabGAP TBC1D1 plays a central role in exercise-regulated glucose metabolism in skeletal muscle. Diabetes, 64(6), 1914-1922. doi:10.2337/db13-1489
  • Hoffman, N. J., Penque, B. A., Habegger, K. M., Sealls, W., Tackett, L., & Elmendorf, J. S. (2014). Chromium enhances insulin responsiveness via AMPK. J Nutr Biochem, 25(5), 565-572. doi:10.1016/j.jnutbio.2014.01.007


Accolades and awards

  • (2015) Australian Physiological Society Postdoctoral Research Publication Prize
  • (2013) Best Poster Presentation: 2nd Annual Garvan Institute Postdoctoral Symposium
  • (2012) Named Chancellor’s Scholar for the IUPUI Graduate School Doctoral Program

Appointments and affiliations

  • (February 2016-present) Postdoctoral Research Fellow
    Australian Catholic University
    Mary MacKillop Institute for Health Research, Exercise and Nutrition Research Program
    Mentor: Professor John Hawley
  • (September 2014-February 2016) Postdoctoral Research Associate
    University of Sydney
    Charles Perkins Centre, School of Molecular Bioscience
    Mentor: Professor David James
  • (March 2012-September 2014) Research Officer
    Garvan Institute of Medical Research, Diabetes and Metabolism Division
    Mentor: Professor David James
  • (May 2008-February 2012) PhD Candidate
    Indiana University School of Medicine, Department of Cellular and Integrative Physiology Mentor: Associate Professor Jeff Elmendorf

Editorial roles

  • (2019) Editorial Board Member, The Asian Journal of Kinesiology

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