2020

Brunser A, Ouyang M, Arima H, Lavados P, Robinson T, Muñoz-Venturelli P, Olavarría V, Billot L, Hackett M, Song L, Middleton S, Pontes-Neto O, Lee TH, Watkins C, Anderson C. No benefit of flat head positioning in early moderate-severe acute ischemic stroke: HeadPoST study subgroup analysis. Stroke and Vascular Neurology. Published online 25 June 2020. http://dx.doi.org/10.1136/svn-2020-000387

Ouyang M, Billot L, Song L, Wang X, Roffe C, Arima H, Lavados P, Hackett M, Olavarría V, Muñoz-Venturelli P, Middleton S, Pontes-Neto O, Lee T, Watkins C, Robinson T, Anderson C. Prognostic significance of urinary catheterization after acute stroke: secondary analyses of the HeadPoST trial. International Journal ofStroke. Published online 19 February 2020. https://doi.org/10.1177/1747493020908140

Jaarsma T, Stromberg A, Dunbar S, Fitzsimon D, Lee C, Middleton S, Vellone E, Freedland K, Riegel B. Self-care research: How to grow the evidence base? International Journal of Nursing Studies 2020; 105: 1-8. https://doi.org/10.1016/j.ijnurstu.2020.103555

Middleton S, Pfeilschifter W on behalf of the QASC Europe Steering Committee, the Angels Initiative, RES-Q, the European Stroke Organisation, and the QASC Europe Project Team.* International Translation of Fever, Sugar, Swallow (FeSS) Protocols: The Quality in Acute Stroke Care (QASC) Europe Project. International Journal of Stroke. 2020. Leading Opinion https://doi.org/10.1177%2F1747493020915130

Cheung N, Campbell L, Middleton, S. Routine glucose assessment in the emergency department for detecting unrecognised diabetes: a cluster randomised trial. Letter to the Editor. Medical Journal of Australia 2020; [Letter]

Fasugba O, Mitchell BG, McInnes E, Koerner J, Cheng AC, Cheng H, Middleton S. Increased fluid intake for the prevention of urinary tract infection in adults and children in all settings: A systematic review. Journal of Hospital Infection. 2020; 104: 68-77. doi.org/10.1016/j.jhin.2019.08.016.

Rogers J, Middleton S, Wilson P, Johnstone S. Predicting functional outcomes after stroke: An observational study of acute single-channel EEG. Topics in Stroke Rehabilitation 2020; 27:(3). 161-172 https://doi.org/10.1080/10749357.2019.1673576

Levi C, Attia JA, D’Este C, Ryan AE, Henskens F, Kerr E, Parsons MW, Sanson-Fisher RW, Bladin C, Lindley RI, Middleton S, Paul CL. Cluster-randomized trial of thrombolysis implementation support in metropolitan and regional Australian stroke centres: Lessons for individual and systems behaviour change. Journal of the American Heart Association 2020; 9(3):e012732. doi: 10.1161/JAHA.119.012732.

2019

Riegel B, Dunbar SB, Fitzsimons D, Freedland KE, Lee CS, Middleton S, Stromberg A, Vellone E, Webber D, Jaarsma T. Self-care research: Where are we now? Where are we going? International Journal of Nursing. Published online 23 August 2019. doi: 10.1016/j.ijnurstu.2019.103402.

Purvis T, Middleton S, Craig L, Kilkenny M, Dale S, Hill K, D'Este C, Cadilhac DA. Inclusion of a care bundle for fever, hyperglycaemia, and swallow management in a National Audit for acute stroke: evidence of upscale and spread. Implementation Science 2019; 14:87. doi: 10.1186/s13012-019-0934-y.

Middleton S, Gardner G, Gardner A, Considine J, Fitzgerald G, Christofis L, Doubrovsky A, Della P, Fasugba O, D’Este C. Are service and patient indicators different in the presence or absence of nurse practitioners? The EDPRAC cohort study of Australian emergency departments. BMJ Open 2019; 9:e024529. doi: 10.1136/bmjopen-2018-024529.

Cheung NW, Campbell L, Fulcher G, McElduff P, Depczynski B, Acharya S, Carter J, Champion B, Chen R, Chipps DR, Flack JR, Kinsella J, Layton M, McLean M, Moses RG, Park K, Poynten A, Pollock C, Scadden D, Tonks K, Webber M, White C, Wong VW, Middleton S. Routine glucose assessment in the emergency department for detecting unrecognised diabetes: a cluster randomised trial. Medical Journal of Australia 2019; 211(10):454–459. https://doi.org/10.5694/mja2.50394 

**Accompanying Editorial: Hare M, Shaw J. Inpatient diabetes care requires adequate support, not just HbA1c screening. Medical Journal of Australia 2019. Published online 17 November 2019. https://doi.org/10.5694/mja2.50391**

Ski CF, van der Wal MHL, Le Grande M, van Veldhuisen DJ, Lesman-Leegt I, Thompson DR, Middleton S, Cameron J, Jaarsma T. Patients with heart failure with and without a history of stroke in the Netherlands: a secondary analysis of psychosocial, behavioural and clinical outcomes up to three years from the COACH trial. BMJ Open 2019; 9: e025525. doi: 10.1136/bmjopen-2018-025525.

Ouyang M, Bowden E, Arima H, Lavados PM, Billot L, Hackett ML, Olavarria VV, Muñoz-Venturelli P, Song L, Rogers K, Middleton S, Pontes-Neto OM, Lee TH, Watkins C, Robinson T, Anderson C on behalf of the HeadPoST investigators. Dysphagia screening and risks of pneumonia and adverse outcomes after acute stroke: an international multicentre study. International Journal of Stroke. Published online 21 June 2019. https://doi.org/10.1177/1747493019858778 

Middleton S, Dale S, Cheung W, Cadilhac D, Grimshaw J, Levi C, McInnes E, Considine J, McElduff P, Gerraty R, Craig L, Schadewaldt V, Fitzgerald M, Quinn C, Cadigan G, Denisenko S, Longworth M, Ward J, D’Este C. Nurse-initiated acute stroke care in Emergency Departments: Results from the T3 implementation cluster randomised controlled trial. Stroke 2019; 50: 1346-1355. doi: 10.1161/STROKEAHA.118.020701.

Muñoz-Venturelli P, Li X, Middleton S, Watkins C, Lavados P, Olavarría V, Brunser A, Pontes-Neto O, Santos T, Arima H, Billot L, Hackett M, Song L, Robinson T, Anderson C. Impact of evidence-based stroke care on patient outcomes: a multilevel analysis of an international study. Journal of The American Heart Association (JAHA) 2019; 8: e012640. doi: 10.1161/JAHA.119.012640.

Tavender E, Babl FE, Middleton S. Review article: A primer for clinical researchers in the emergency department: Part 8. Implementation Science: An introduction. Emergency Medicine Australasia (EMA) Journal 2019; 31:332-338. doi.org/10.1111/1742-6723.13296

Cadilhac DA, Grimley R, Kilkenny MF, Andrew NE, Lannin NA, Hill K, Grabsch B, Levi CR, Thrift AG, Faux SG, Wakefield J, Cadigan G, Donnan GA, Middleton S, Anderson CS. Multicenter, prospective, controlled, before-and-after, quality improvement study (Stroke 123) of acute stroke care. Stroke 2019; 50(6): 1525-1530. doi.org/10.1161/STROKEAHA.118.023075.

Minhas J, Wang X, Lavados P, Moullaali T, Arima H, Billot L, Hackett M, Olavarría V, Middleton S, Pontes-Neto O, de Silva A, Lee T, Pandian J, Mead G, Watkins C, Chalmers J, Anderson C, Robinson T. Blood pressure variability and outcome in acute ischemic and hemorrhagic stroke: A post-hoc analysis of the HeadPoST study. Journal of Human Hypertension 2019; 33: 411-418. doi: 10.1038/s41371-019-0193-z

Rogers JM, Duckwork J, Middleton S, Steenbergen V, Wilson PH. Elements virtual rehabilitation improves motor, cognitive, and functional outcomes in adult stroke: evidence from a randomized controlled pilot study. Journal of NeuroEngineering and Rehabilitation 2019; 16:56. https://doi.org/10.1186/s12984-019-0531-y

Cadilhac D, Kilkenny M, Lannin N, Dewey H, Levi C, Hill K, Grabsch B, Grimley R, Blacker D, Thrift A, Middleton S, Anderson C, Donnan G. Outcomes for patients with in-hospital stroke: a multicentre study from the Australian Stroke Clinical Registry. Journal of Stroke and Cerebrovascular Diseases 2019; 28(5): 1302-1310. doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.026

Schadewaldt V, McElduff B, D’Este C, McInnes E, Dale S, Gunaratne A, Squires J, Cadilhac DA, Middleton S. Validating the Alberta Context Tool in a multi-site Australian Emergency Department nurse population. Plos One 2019; 14(4): e0215153. doi: doi.org/10.1371/journal.pone.0215153

Middleton S, McElduff P, Drury P, D’Este C, Cadilhac DA, Dale S, Grimshaw J, Ward J, Quinn C, Cheung NW, Levi C. Vital sign monitoring following stroke associated with 90-day independence: a secondary analysis of the QASC cluster randomized trial. International Journal of Nursing Studies 2019; 89: 72-79. doi.org/10.1016/j.ijnurstu.2018.09.014

Craig LE, Middleton S, Hamilton H, Cudlip F, Swatzell V, Alexandrov AV, Lightbody E, Watkins C, Philip S, Cadilhac DA, McInnes E, Dale S, Alexandrov AW. Does the Addition of Non-Approved Inclusion and Exclusion Criteria for rtPA Impact Treatment Rates? Findings in Australia, the UK, and the USA. Interventional Neurology 2019; 8(1):1–12. doi.org/10.1159/000493020

Kilkenny M, Kim J, Andrew N, Sundararajan V, Thrift AG, Katzenellenbogen JM, Flack F, Gattellari M, Boyd JH, Anderson P, Lannin N, Sipthorp M, Chen Y, Johnston T, Anderson CS, Middleton S, Donnan GA, Cadilhac DA. Maximising data value and avoiding data waste: a validation study in stroke research. Medical Journal of Australia 2019; 210 (1): 27-31 doi: 10.5694/mja2.12029

** In top 10% most downloaded papers between Jan 2018 and Dec 2019 **

Andrew NE, MiddletonS, Grimley R, Anderson CS, Donnan GA, Lannin NA, Stroil-Salama E, Grabsch B, Kilkenny MF, Squires JE, Cadilhac DA and on behalf of the Stroke123 Investigators. Hospital organizational context and delivery of evidence-based stroke care: a cross-sectional study. Implementation Science. 2019; 14:6. doi.org/10.1186/s13012-018-0849-z 

** The Correction to this article has been published in Implementation Science 2019 14(13). https://doi.org/10.1186/s13012-019-0862-x

Rogers JM, Bechara J, MiddletonS, Johnstone SJ. Acute EEG patterns associated with transient ischemic attack. Clinical EEG & Neuroscience 2019; 50(3): 196-204. doi: 10.1177/1550059418790708

2018

Godecke E, Rai T, Cadilhac DA, Armstrong E, Middleton S, Ciccone N, Whitworth A, Rose ML, Holland A, Ellery F, Hankey GJ, Bernhardt J for the VERSE Collaboration. Statistical analysis plan (SAP) for the Very Early Rehabilitation in Speech (VERSE) after stroke trial: an international 3-arm clinical trial to determine the effectiveness of early, intensive, prescribed, direct aphasia therapy. International Journal of Stroke 2018; 13(8): 863-880. doi: 10.1177/1747493018790055

Lynch E, Ramanathan S, Middleton S, Bernhard J, Nilsson M, Cadilhac DA. A mixed methods study to explore opinions of research translation held by researchers working in a Centre of Research Excellence in Australia. BMJ Open 2018; 8: e022357. [Online publication]

doi: 10.1136/bmjopen-2018-022357

Kilkenny M, Lannin N, Levi C, Faux S, Dewey H, Grimley R, Hill K, Grabsch B, Kim J, Hand P, Crosby V, Gardner M, Rois-Gnecco J, Thijs VN, Anderson CS, Donnan G, Middleton S, Cadilhac DA on behalf of the AuSCR Consortium. Weekend hospital discharge is associated with suboptimal care and outcomes: An observational Australian Stroke Clinical Registry study. International Journal of Stroke 2018; 14(4) 430–438. doi: 10.1177/1747493018806165

Malone V, Ezard N, McInnes E, Clifford B, Bonevski B, Middleton S. A systems change intervention for nurse-led smoking cessation care in hospitals. Collegian 2018; 26(2): 235-241. doi: 10.1016/j.colegn.2018.07.007.

Busingye D, Kilkenny MF, Purvis T, Kim J, Middleton S, Campbell BCV, Cadilhac DA. Is length of time in a stroke unit associated with better outcomes for patients with stroke in Australia? An observational study. BMJ Open 2018; 8(11): e022536. [Online publication]

doi: 10.1136/bmjopen-2018-022536

Ramanathan S, Reeves P, Deeming S, Berrnhardt J, Nilsson M, Cadilhac DA, Walker R, Carey L, Middleton S, Lynch E, Searles A. Implementing a protocol for a research impact assessment of the Centre for Research Excellence in Stroke Rehabilitation and Brain Recovery. Health Research Policy and Systems 2018; 16:71. doi.org/10.1186/s12961-018-0349-2.

Morgan P, Coleman P, Martinez-Garduno C, Gunaratne A, McInnes, E, Middleton S. Implementation of a patient blood management program in an Australian private hospital Orthopaedic Unit. Journal of Blood Medicine 2018; 9: 83-90. DOI: 10.2147/jbm.s157571

Muller C, Cheung WA, Dewey H, Churilov L, Middleton S, Thijs V, Ekinci E, Levi C, Lindley R, Donnan GA, Parsons M, Bladin C. Treatment with Exenatide in Acute Ischaemic Stroke (TEXAIS) trial Protocol: a prospective, randomised, open label, blinded end-point study of Exenatide vs. Standard Care in Post Stroke Hyperglycaemia. International Journal of Stroke 2018; 13(8): 857–862. https://doi.org/10.1177/1747493018784436

Alexandrov AW, Palazzo P, Biby S, Doerr A, Dusenbury W, Young R, Lindstrom A, Grove M, Tsivgoulis G, Middleton S, Alexandrov AV. Back to basics: Adherence with guidelines for glucose and temperature control in an American comprehensive stroke center sample. Journal of Neuroscience Nursing 2018; 50(3): 131-137. doi:10.1097/JNN.0000000000000358

Aminov A, Rogers J, Middleton S, Caeyenberghs K, Wilson PH. What do randomized controlled trials say about virtual rehabilitation in stroke? A systematic literature review and meta-analysis of upper-limb and cognitive outcomes. Journal of NeuroEngineering and Rehabilitation 2018; 15:29. doi: 10.1186/s12984-018-0370-2

Haines MM, Brown B, D’Este CA, Yano EM, Craig JC, Middleton S, Castaldi PA, Pollock CA, Needham K, Watt WH, Elliott EJ, Scott A, Dominello A, Klineberg E, Atkinson J, Paul C, Redman S, on behalf of the Clinical Networks Research Group. Improving the quality of healthcare: a cross-sectional study of the features of successful clinical networks. Public Health Research Practice 2018; 28 (4): e28011803 doi.org/10.17061/phrp28011803

Kilkenny MF, Lannin NA, Anderson CS, Dewey H, Kim J, Barclay-Moss K, Levi C, Faux S, Hill K, Grabsch B, Middleton S, Thrift A, Grimley R, Donnan G, Cadilhac D. Quality of life is poorer for patients with stroke who require an interpreter: An observational Australian Registry study. Stroke 2018; 49(3): 761-764. doi: 10.1161/STROKEAHA.117.019771

Cadilhac DA, Andrew NE, Kilkenny MF, Hill K, Grabsch B, Lannin NA, Thrift A, Anderson CS, Donnan GA, Middleton S, Grimley R. Improving quality and outcomes of stroke care in hospitals: protocol and statistical analysis plan for the Stroke123 implementation study. International Journal of Stroke 2018; 13(1): 96-106. doi: 10.1177/174749301773074

Andrew NE, Kim J, Thrift AG, Kilkenny MF, Lannin NA, Anderson CS, Donnan GA, Hill K, Middleton S, Levi C, Faux S, Grimley R, Gange N, Geraghty R, Ermel S, Cadilhac DA. Prescription of antihypertensive medication at discharge influences survival following stroke. Neurology 2018; 90(9): e745-e753. doi: 10.1212/WNL.0000000000005023

Gardner G, Gardner A, Middleton S, Considine J, Fitzgerald G, Christofis L, Doubrovsky A, Adams M, O’Connell J. Mapping workforce configuration and operational models in Australian Emergency Departments: A national survey. Australian Health Review 2018; 42(3): 340-347. doi: 10.1071/AH16231

2017

Purvis T, Kilkenny MF, Middleton S, Cadilhac DA. Influence of stroke coordinators on delivery of acute stroke care and hospital outcomes: An observational study. International Journal of Stroke 2017; 13(6): 585-591. doi: 10.1177/1747493017741382.

Lannin NA, Anderson CS, Kim J, Kilkenny M, Bernhardt J, Levi C, Dewey H, Bladin C, Hand P, Castley J, Hill K, Faux S, Grimley R, Grabsch B, Middleton S, Donnan G, Cadilhac DA. Treatment and outcomes of working aged adults with stroke: results from a national prospective registry. Neuroepidemiology 2017; 49(3-4): 113-120. doi: 10.1159/000484141

Middleton S, Bruch D, Martinez-Garduno C, Dale S, McNamara M. International uptake of a proven intervention to reduce death and dependency in acute stroke: A cross-sectional-survey following the QASC Trial. Worldviews on Evidence-Based Nursing 2017; 14(6):447-454. doi: 10.1111/wvn.12253

Luker J, Bernhardt J, Graham I, Middleton S, Lynch E, Thayabaranathan T, Craig L, Cadilhac D, O’Connor D, Miller P, Tavender E. Interventions for the uptake of evidence-based recommendations in acute stroke settings. Cochrane Database of Systematic Reviews 2017; Issue 1. Art. No.: CD012520. DOI: 10.1002/14651858.CD012520

Aminov A, Rogers JM, Wilson PH, Johnstone SJ, Middleton S. Acute single channel EEG predictors of cognitive function after stroke. PLOS ONE 2017; 12(10): e0185841. https://doi.org/10.1371/journal.pone.0185841

Ferguson C, Inglis SC, Newton PJ, Middleton S, Macdonald PS, Davidson PM. Barriers and enablers to adherence to anticoagulation in heart failure with atrial fibrillation: patient and provider perspectives. Journal of Clinical Nursing 2017; 26(23-24): 4325-4334. DOI: 10.1111/jocn.13759.

Kawano H, Bivard A, Parsons M, Paul C, Krause M, D’Este C, Bladin C, Lindley R, Attia J, Henskens F, Longworth M, Middleton S, Ryan A, Kerr E, Sanson-Fisher R, Levi C. Hospital arrival times and post-imaging delays in stroke thrombolysis implementation. Journal of Neurological Disorders & Stroke 2017; 5(3): 1127-1132.

Billot L, Woodward M, Arima H, Hackett M, Munoz Venturelli P, Lavados P, Brunser A, Peng B, Cui L, Song L, Heritier S, Jan S, Middleton S, Olavarría V, Lim J, Robinson T, Anderson CS. Statistical analysis plan for the Head Position in Stroke Trial (HeadPoST): an international cluster cross-over randomised trial. International Journal of Stroke 2017; 12(6): 667-670.

Westbrook JI, Li L, Hooper TD, Raban MZ, Middleton S, Lehnbom EC. Effectiveness of a ‘Do not interrupt’ bundled intervention to reduce interruptions during medication administration: A cluster randomised controlled feasibility study. BMJ Quality & Safety 2017; 26: 734-742.

Cadilhac DA, Andrew NE, Salama ES, Hill K, Middleton S, Horton E, Meade I, Kuhle S, Nelson MR, Grimley R, Australian Stroke Clinical Registry Consortium. Improving discharge care: the potential of a new organisational intervention to improve discharge after hospitalisation for acute stroke, a controlled before-after pilot study. BMJ Open 2017; 7(8): e016010.

DOI: 10.1136/bmjopen-2017-016010

Mikulik R, Ylikotila P, Roine R, Brozman M, Middleton S. Leaving a legacy of Stroke in Europe: A community of dedicated professionals is changing the face of stroke in Europe. Oruen – The CNS Journal 2017; 3(1): 8-18.

Craig L, Taylor B, Grimley R, Cadilhac D, McInnes E, Phillips R, Dale S, O’Connor D, Levi C, Fitzgerald M, Considine J, Grimshaw J, D’Este C, Gerraty R, Cheung W, Ward J, Middleton S. Development of a theory-informed implementation intervention to improve the triage, treatment and transfer of stroke patients in emergency departments using the Theoretical Domains Framework (TDF): The T3 Trial. Implementation Science 2017; 12: 88.

Anderson CS, Arima H, Lavados P, Billot L, Hackett ML, Olavarria VV, Munoz-Venturelli P, Brunser A, Peng B, Cui L, Song L, Rogers K, Middleton S, Lim JY, Forshaw D, Lighbody CE, Woodward M, Pontes-Neto O, de Silva A, Lin RT, Lee TH, Pandian JD, Mead GE, Robinson T, Watkins C for the HeadPoST Investigators and Coordinators. Cluster-Randomized, Crossover trial of head positioning in acute stroke. New England Journal of Medicine 2017; 376: 2437-2447.

Cadilhac D, Kilkenny M, Levi C, Lannin N, Thrift A, Kim J, Grabsch B, Churilov L, Dewey H, Hill K, Faux S, Grimley R, Castley H, Hand P, Wong A, Herkes G, Gill M, Crompton D, Middleton S, Donnan G, Anderson C. Risk-adjusted mortality rates following stroke by hospital: evidence from the Australian Stroke Clinical Registry (AuSCR). Medical Journal of Australia 2017; 206(8): 345-350.

Ferguson C, Inglis S, Newton P, Middleton S, Macdonald P, Davidson P. Multi-morbidity, frailty and self-care: important considerations in treatment with anticoagulation drugs. Outcomes of the AFASTER study. European Journal of Cardiovascular Nursing 2017; 16(2): 113-124. doi:10.1177/1474515116642604

Craig LE, Churilov L, Olenko L, Cadilhac DA, Grimley R, Dale S, Martinez-Garduno C, McInnes E, Considine J, Grimshaw JM, Middleton S. Testing a systematic approach to identify and prioritise barriers to successful implementation of a complex healthcare intervention. BMC Medical Research Methodology 2017; 17: 24.

Middleton S, Coughlan K, Mnatzaganian G, Choy N, Dale, S, Jammali-Blasi A, Levi C, Grimshaw J, Ward J, Cadilhac D, McElduff P, Hiller J, D’Este C. Mortality reduction for fever, hyperglycaemia and swallowing nurse-initiated stroke intervention: QASC trial follow-up. Stroke 2017; 48: 1331-1336.

Cadilhac DA, Andrew N, Lannin N, Middleton S, Levi C, Dewey H, Grabsch B, Faux S, Hill K, Grimley R, Wong A, Sabet A, Butler E, Bladin C, Bates T, Groot P, Castley H, Donnan G, Anderson C. Quality of acute care and long-term quality of life and survival: the Australian Stroke Clinical Registry. Stroke 2017; 48(4): 1026 – 1032.

Dennis S, Reddel H, Middleton S, Hasan I, Hermiz O, Phillips R, Crockett A, Vagholkar S, Marks G, Zwar N. Barriers and outcomes of an evidence based approach to diagnosis and management of chronic obstructive pulmonary disease (COPD) in Australia: A qualitative study. Family Practice 2017; 34(4): 485-490. DOI: 10.1093/fampra/cmw103

2016

Craig LE, McInnes E, Taylor N, Grimley R, Cadilhac DA, Considine J, Middleton S. Identifying the barriers and enablers for a triage, treatment and transfer clinical intervention to manage acute stroke patients in the emergency department: A systematic review using the theoretical domains framework (TDF). Implementation Science 2016; 11: 157.

Ferguson C, Hickman LD, Lal S, Newton PJ, Kneebone I, Mcgowan S, Middleton S. Addressing the stroke evidence-treatment gap. Contemporary Nurse 2016; 52(2-3): 253-257.

**Invited Editorial**

Middleton S, Levi C, Dale S, Cheung NW, McInnes E, Considine J, D’Este C, Cadilhac DA, Grimshaw J, Gerraty R, Craig L, Schadewaldt V, McElduff P, Fitzgerald M, Quinn C, Cadigan G, Denisenko S, Longworth M, Ward J and T3 Trialist Collaborators. Triage, Treatment and Transfer of Patients with Stroke in Emergency Departments Trial (The T3 Trial): A cluster randomised trial protocol. Implementation Science 2016; 11: 139.

Muñoz-Venturelli P, Robinson T, Lavados PM, Olavarría VV, Arima H, Billot L, Hackett ML, Lim JY, Middleton S, Pontes-Neto O, Peng B, Cui L, Song L, Mead G, Watkins C, Lin R, Lee T, Pandian J, Asita de Silva H, Anderson CS, for the HeadPoST Investigators. Regional Variation in Acute Stroke Care Organisation. Journal of the Neurological Sciences 2016; 371: 126-130.

Brown B, Haines M, Middleton S, Paul C, D’Este C, Klineberg E, Elliot E on behalf of the Clinical Networks Research Group. Development and validation of a survey to measure features of clinical networks. BMC Health Services Research 2016; 16: 531.

Zwar N, Bunker J, Reddel H, Dennis S, Middleton S, van Schayck O, Crockett A, Hasan I, Hermiz O, Vagholkar S, Xuan W, Marks G. Early intervention for chronic obstructive pulmonary disease by practice nurse and GP teams: a cluster randomised trial. Family Practice 2016; 33(6): 633-670.

Jammali-Blasi A, McInnes E, Middleton S. A survey of acute care clinicians’ views on factors influencing hand hygiene practice and actions to improve hand hygiene compliance. Infection, Disease & Health 2016; 21: 16-25.

Ferguson C, Inglis, CS, Newton PJ, Middleton S, Macdonald PS, Davidson PM. Multimorbidity, frailty and self-care: Important considerations in anticoagulation. Outcomes of the AFASTER study. European Journal of Cardiovascular Nursing 2016; 1-12.

Cadilhac D, Kim J, Lannin NA, Levi CR, Dewey HM, Hill K, Faux S, Andrew N, Kilkenny MF, Grimley R, Thrift AG, Grabsch B, Middleton S, Anderson CS, Donnan GA. Better outcomes for hospitalized patients with TIA when in stroke units. Neurology 2016; 86(22): 2042-2048. Epub 2016 May 4.

Godecke E, Armstrong E, Rai T, Middleton S, Ciccone N, Whitworth A, Rose M, Holland A, Ellery F, Hankey G, Cadilhac D, Bernhardt J. A randomised controlled trial of Very Early Rehabilitation in Speech (VERSE) after stroke. International Journal of Stroke 2016; 11(5): 586-592.

Ferguson C, Inglis SC, Newton PJ, Middleton S, Macdonald PS, Davidson PM. Education and practice gaps on atrial fibrillation and anticoagulation: A survey of cardiovascular nurses. BMC Medical Education 2016; 16: 9.

McCluskey A, Ada L, Kelly PJ, Middleton S, Goodall S, Grimshaw JM, Logan P, Longworth M, Karageorge A. A behaviour change program to increase outings delivered during therapy to stroke survivors by community rehabilitation teams: The Out-and-About trial. International Journal of Stroke 2016; 11(4): 425-37.

Middleton S, Lydtin A, Comerford D, Cadilhac DA, McElduff P, Dale S, Hill K, Longworth M, Ward J, Cheung NW, D’Este C on behalf of the QASCIP Working Group and Steering Committee. From QASC to QASCIP: successful Australian translational scale-up and spread of a proven intervention in acute stroke using a prospective pre-test/ post-test study design. BMJ Open 2016; 6(5): e011568.

Drury P, McInnes E, Hardy J, Dale S, Middleton S. Stroke unit nurse manager’s views of the influence of individual and organisational factors on evidence-based practice: a survey. International Journal of Nursing Practice 2016; 22(2): 169-78.

Middleton S, Gardner A, Della P, Lam L, Allnutt N, Gardner G. How has the profile of Australian Nurse practitioners changed over time? Collegian: The Australian Journal of Nursing Practice, Scholarship and Research 2016; 23: 69-77.

2015

McInnes E, Haines M, Dominello A, Kalucy D, Jammali-Blasi A, Middleton S, Klineberg E. What are the reasons for clinical network success? A qualitative study of stakeholder views. BMC Health Services Research 2015; 15: 497.

Middleton S, Grimlely R, Alexandrov A. Triage, Treatment and Transfer: Evidence-based clinical practice recommendations and models of nursing care for the first 72 hours of admission to hospital for acute stroke. Stroke 2015; 46: 18-25.

McCluskey A, Ada L, Patrick J Kelly PJ, Middleton S, Goodall S, Grimshaw JM, Logan P, Longworth M, Karageorge A. Compliance with Australian guideline recommendations for outdoor mobility and transport training by post-inpatient rehabilitation services: An observational cohort study. BMC Health Services Research 2015; 15(1): 296.

Dale S, Levi C, Ward J, Grimshaw J, Jammali-Blasi A, D' Este C, Griffiths R, Quinn C, Evans M, Cadilhac D, Cheung NW, Middleton S. Barriers and enablers to implementation clinical treatment protocols for fever, hyperglycaemia and swallowing dysfunction in the Quality in Acute Stroke Care (QASC) Project - a mixed methods study. Worldviews on Evidence Based Nursing 2015; 12(1): 41-50.

Munoz-Venturelli P, Arima H, Lavados P, Brunser A, Peng B, Cui L, Song L, Billot L, Boden E, Hackett ML, Heritier H, Jan S, Middleton S, Olavarria VV, Lim J, Lindley RI, Heeley E, Robinson T, Pontes-Neto O, Lkhamtsoo N, Lin RT, Watkins C, Anderson C. Head Position in Stroke Trial (HeadPoST) – sitting-up vs lying-flat positioning of patients with acute stroke: study protocol for cluster randomized controlled trial. Trials 2015; 16: 256.

Knowles S, Lawrence T, McInnes E, Elliott D, Hardy J, Middleton S^. Knowledge, attitudes, beliefs and behaviour intentions for three bowel management practices in intensive care: effects of a targeted protocol implementation for nursing and medical staff. BMC Nursing 2015; 14: 6.

2014

Ferguson C, Inglis SC, Newton PJ, Middleton S, Macdonald PS, Davidson PM. The caregiver role in thromboprophylaxis management in atrial fibrillation: a literature review. European Journal of Cardiovascular Nursing 2014; 14(2): 98-107.

McInnes E, Phillips R, Middleton S, Gould D. A Qualitative Study of Senior Hospital Managers' Views on Current and Innovative Strategies to Improve Hand Hygiene Compliance. BMC Infectious Diseases 2014; 14: 611.

**Editor’s Choice**

Ferguson C, Inglis SC, Newton PJ, Middleton S, Macdonald PS, Davidson PM. Atrial fibrillation: stroke prevention in focus. Australian Critical Care 2014; 27(2): 92-98.

Drury P, Levi C, D’Este C, McElduff P, McInnes E, Hardy J, Dale S, Cheung NW, Grimshaw J, Quinn C, Ward J, Evans M, Cadilhac D, Griffiths R, Middleton S^. Quality in Acute Stroke Care (QASC): Process evaluation of an intervention to improve the management of fever, hyperglycaemia, and swallowing dysfunction following acute stroke. International Journal of Stroke 2014; 9(6): 766-776.

Chan D, Levi C, Cordato D, O’Rourke F, Chen J. Redmond H, Xu Y, Middleton S, Pollack M, Hankey G. Health Service Management Study for Stroke: A randomised controlled trial to evaluate two models of stroke care. International Journal of Stroke 2014; 9: 400-405.

Paul C, Levi C, D’Este C, Parsons M, Bladin C, Lindley R, Attia J, Carey M, Henskens F, Lalor E, Longworth M, Middleton S, Ryan A, Kerr E, Sanson-Fischer R. Thrombolysis ImPlementation in Stroke (TIPS): Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice. Protocol for a cluster randomised controlled trial in acute stroke care. Implementation Science 2014; 9: 38.

Knowles S, McInnes E, Elliot D, Hardy J, Middleton S^. Evaluation of the implementation of a bowel management protocol in Intensive Care: Effect on clinician practices and patient outcomes. Journal of Clinical Nursing 2014; 23: 716-730.

Drury P, Levi C, McInnes E, Hardy J, Ward J, Grimshaw J, D’Este C, Dale S, McElduff P, Cheung NW, Quinn C, Griffiths R, Evans M, Cadilhac D, Middleton S^. Management of fever, hyperglycaemia and swallowing dysfunction following acute stroke admission in New South Wales (NSW) Australia. International Journal of Stroke 2014; 9(1): 23-31.

2013

Duff J, Omari A, Middleton S, McInnes E, Walker K. Educational outreach visits to improve venous thromboembolism prevention in hospitalised medical patients: a prospective before-and-after intervention study. BMC Health Services Research 2013; 13: 398.

Duff J, Walker K, Middleton S, McInnes E. Educational Outreach Visits to improve nurses' use of mechanical venous thromboembolism prevention in hospitalised medical patients. Journal of Vascular Nursing 2013; 31(4): 139-149.

Middleton S, Lyons N. In reply - Stroke care in Australia: why is it still the poor cousin of health care? Letter to the Editor. Medical Journal of Australia 2013; 199(3): 166. [Letter]

Middleton S, Rowley J, Hillege S, Hill K, Churilov L, Allnutt N. Clinical Guidelines for Acute Stroke Management: Which recommendations should remain consensus-based? Journal of Vascular Nursing 2013; 31: 72-83.

Ahern T, Gardner A, Gardner G, Middleton S, Della P. Development and inter-rater reliability testing of a telephone interview training program for Australian nurse interviewers. Nurse Education Today 2013; 33(5): 470-474.

Ferguson C, Inglis S, Newton P, Middleton S. Macdonald P, Davidson T. Atrial fibrillation and thromboprophylaxis in heart failure: The need for patient centered approaches to address adherence. Vascular Health and Risk Management 2013; 9: 3–11.

McCluskey A, Ada L, Middleton S, Kelly PJ, Goodall S, Grimshaw JM, Logan P, Longworth M, Karageorge A. Improving quality of life by increasing outings after stroke: Study protocol for the Australian Out-and-About trial. International Journal of Stroke 2013; 8(1): 54–58.

Chan DKY, Cordato D, O’Rourke F, Chan DL, Pollack M, Middleton S, Levi C. Comprehensive stroke units: A review of comparative evidence and experience. International Journal of Stroke. 2013; 8(4): 260-264.

2012

Sutherland-Fraser S, McInnes E, Maher E, Middleton S^. Peri-operative nurses’ knowledge and reported practice of pressure ulcer risk assessment and prevention: A before-after intervention study. BMC Nursing 2012; 11: 25.

Zwar N, Hermiz O, Hasan I, Comino E, Middleton S, Marks G, Vagholkar S, Wilson S, Xuan W. Care of patients with a diagnosis of chronic obstructive pulmonary disease: a cluster randomised controlled trial. Medical Journal of Australia 2012; 197(7): 394-398.

** Editor’s Choice **

** Awarded MJA Prize for Excellence in General Practice Research June 2013 **

Bunker J, Reddel HK, Dennis S, Middleton S, Van Schayck CP, Crockett AJ, Hasan I, Hermiz O, Vagholkar S, Marks GB, Zwar NA. A pragmatic cluster randomized controlled trial of early intervention for chronic obstructive pulmonary disease by practice nurse GP teams: Study protocol. Implementation Science 2012; 7: 83.

Middleton S. Keeping It Simple: The power of three clinical protocols. Journal of Clinical Nursing 2012; 21: 3195–3197.

** Invited Editorial **

Lannin N, Ada L, Lindley R, McCluskey A, Middleton S, Quinn C, Longworth M. Stroke clinicians’ priorities for stroke research. Journal of Allied Health Sciences and Practice 2012; 10: 4.

Duff J, Di Staso R, Cobbe KA, Draper N, Tan S, Halliday E, Middleton S, Lam L, Walker K. Preventing hypothermia in elective arthroscopic shoulder surgery patients: a protocol for a randomised controlled trial. BMC Surgery 2012; 12: 14.

Wright L, Hill K, Berhardt J, Lindley R, Middleton S^. On behalf of the National Stroke Foundation Stroke Guidelines Expert Working Group. Stroke Management – updated recommendations for treatment along the care continuum. Internal Medicine Journal 2012; 42(5): 562-9. doi: 10.1111/j.1445-5994.2012.02774.x

Middleton S. Doing the Simple Things Well. Collegian 2012; 19: 65-66.

** Invited Editorial **

Middleton S, D’Este C, Grimshaw J, Ward J, Levi C on behalf on the Quality in Acute Stroke Care (QASC) trial investigators. Invited Authors Reply. TheLancet 2012; 379(9824): 1390. [Letter]

Middleton S, Levi C, Ward J on behalf on the Quality in Acute Stroke Care (QASC) trial investigators. Quality in Acute Stroke Care trial: Swallow surveillance rates comparable with international data. Letter to the Editor. The Lancet 2012; 379(9824): 1389. [Letter]

Middleton S. An outcomes approach to stroke care: The importance of teamwork and good nursing care. International Journal of Stroke 2012; 7: 224–226.

** Invited Leading Opinion **

Haines M, Brown B, Craig J, D’Este C, Elliott E, Klineberg E, McInnes E, Middleton S, Paul C, Redman S, Yano EM. On behalf of the Clinical Networks Research Group. Determinants of successful clinical networks: the conceptual framework and study protocol. Implementation Science 2012; 7:16. doi: 10.1186/1748-5908-7-16

McInnes E, Middleton S, Gardner G, Haines M, Haertsch M, Paul C, Castaldi P. A qualitative study of stakeholder views of the conditions for and outcomes of successful clinical networks. BMC Health Services Research 2012 Feb 28; 12: 49. doi: 10.1186/1472-6963-12-49

Barnsley L, McCluskey A, Middleton S. What people say about travelling outdoors after their stroke: A qualitative study. Australian Occupational Therapy Journal 2012; 59: 71–78.

Middleton S, McElduff P, Ward J, Grimshaw J, Dale S, D’Este C, Drury P, Griffiths R, Cheung NW, Quinn C, Evans M, Cadilhac D, Levi C. Implementation of evidence-based treatment protocols to manage fever, hyperglycaemia and swallowing dysfunction in acute stroke improves 90-day outcomes: QASC, a cluster randomised controlled trial. The Lancet 2011; 378(9804): 1699-1706.

Published online October 12: 1-8. DOI:10.1016/S0140-6736(11)61485-2.

***** Commentary also published in The Lancet ***** See:

Wolfe CDA and Rudd AG. Improvement of Care in Acute Stroke Units. The Lancet 2011; 378 (9804): 1679. Published online 12 October 2011 DOI:10.1016/S0140-6736(11)61545-6.

***** Published in Faculty 1000 (F1000) Library as a result of post-publication peer review which places this work in the library of the top 2% of published articles in biology and medicine available at http://f1000.com/13399002. *****

***** Commentary published in Annals of Internal Medicine ***** See:

Alberts MJ. ACP Journal Club: The Best Evidence for Patient Care. Annals of Internal Medicine 2012; 156(3): JC3-09.

2011

Middleton S, Levi C, Ward J, Grimshaw J, Griffiths R, D’Este C, Dale S, Quinn C, Evans M, Cadilhac D, McElduff. Death, Dependency and Health Status 90-Days following hospital admission for acute stroke in NSW. Internal Medicine Journal 2011; 41(10): 736-742.

Zwar N, Marks G, Hermiz O, Middleton S, Comino E, Hasan I, Vagholkar S, Wilson S. Predictors of Accuracy of Diagnosis of Chronic Obstructive Pulmonary Disease in General Practice. Medical Journal of Australia 2011; 195: 168-171.

Middleton S, Gardner A, Gardner G, Della P. The status of Australian nurse practitioners: the second national census. Australian Health Review 2011; 35: 448–454, available at http://dx.doi.org/10.1071/AH10987.

Perry L, Middleton S. An investigation of family carers’ needs following stroke survivors’ discharge from acute hospital care in Australia. Disability and Rehabilitation 2011; 33(19–20): 1890–1900.

Jammali-Blasi A, McInnes E, Markus R, Faux S, O’Loughlin G, Dale S, Middleton S^. 90-day outcomes for a cohort of patients admitted to a metropolitan acute stroke unit. Journal of Vascular Nursing 2011; 29(1): 3-10.

Jordan L A, Mackey E, Coughlan K, Wyer M, Allnutt N, Middleton S ^. Continence management in acute stroke: A survey of current national practices. Journal of Advanced Nursing 2011; 67(1): 94-104.

2010

McMaster R, Hawley R, Fletcher T, Gillett W, McDermott S, Middleton S^. Evaluation of a Housing Support program for people who are at risk of homelessness: Perspective of people who refer clients. Journal of Social Distress and the Homeless 2010; 19(3-4): 18-46.

Sangvatanakul P, Hillege S, Lalor E, Levi C, Hill K, Middleton S^. Setting stroke research priorities: The consumers’ perspective. Journal of Vascular Nursing, 2010; 28(4): 121-131.

Walker K, Middleton S, Rolley J, Duff J. Nurses report a healthy culture: results of the practice environment scale (PES-AUS) in an Australian hospital seeking magnet recognition. International Journal of Nursing Practice, 2010; 16(6): 616-623.

Gardner G, Gardner A, Middleton S, Della P, Doubrovsky A. A snapshot of Australian nurse practitioners’ extended practice activities. Nurse Practitioner Series 2010; 3(1): 8-15.

Middleton S, Gardner G, Gardner A, Della P, Gibb M, Millar L. The first Australian nurse practitioner census: A protocol to guide standardised collection of information about an emergent professional group. International Journal of Nursing Practice 2010; 16: 517-524.

Gardner G, Gardner A, Middleton S, Della P, Kain V, Doubrovsky A. The work of nurse practitioners. Journal of Advanced Nursing 2010; 66(10): 2160-2169.

** Editor’s Choice **

McCluskey A, Middleton S. Increasing delivery of an outdoor journey intervention to people with stroke: A feasibility study involving five community rehabilitation teams. Implementation Science 2010; 5: 59.

Cadilhac DA, Lannin N, Anderson C, Levi C, Faux S, Price C, Middleton S, Lim J, Thrift A, Donnan G. Protocol and pilot data for establishing the Australian Stroke Clinical Registry (AuSCR). International Journal of Stroke 2010; 5(3): 217-226.

Gardner G, Gardner A, Middleton S, Gibb M, Della P, Duffield C. Development and validation of a novel approach to work sampling: a study of nurse practitioner work patterns. Australian Journal of Advanced Nursing 2010; 27(4): 4-12.

Allnutt J, Allnutt N, McMaster R, O’Connell J, Hillege S, Middleton S^, Della P, Gardner G, Gardner A. Clients’ understanding of the role of Nurse Practitioners in Australia. Australian Health Review 2010; 34: 59-65.

McCluskey A, Middleton S. Delivering an evidence-based outdoor journey intervention to people with stroke: Barriers and enablers experienced by community rehabilitation teams. BMC Health Services Research 2010; 10: 18.

Knowles S, Rolls K, Elliott D, Hardy J, Middleton S. Patient care guidelines: A telephone survey of intensive care practices in New South Wales. Australian Critical Care 2010; 23: 21-29.

2009

Middleton S, Walker K, Leigh T. Why Fellowship? Peak professional bodies, peer recognition and credentialing in Australia. Collegian 2009; 16: 177-183.

Available at http://dx.doi.org/10.1016/j.colegn.2009.06.002

Gardner A, Gardner G, Middleton S, Della P. The status of Australian Nurse Practitioners: Findings from the first national census. Australian Health Review 2009; 33(4): 679–689.

Middleton S, Levi C, Ward J, Grimshaw J, Griffiths R, D’Este C, Dale S, Cheung NW, Quinn C, Evans M, Cadilhac D. Fever, hyperglycaemia and swallowing dysfunction management in acute stroke: A cluster randomised controlled trial of knowledge transfer. Implementation Science 2009; 4: 16. doi:10.1186/1748-5908-4-16.

Hill K, Middleton S^, O’Brien E, Lalor E. Implementing clinical guidelines for acute stroke management: Do nurses have a lead role? Australian Journal of Advanced Nursing 2009; 26(3): 53-58.

Gattellari M, Worthington J, Zwar N, Middleton S. The management of non-valvular atrial fibrillation (NVAF) in Australian, general practice: bridging the evidence-practice gap. A national, representative needs assessment survey. BMC Family Practice 2008; 9: 62.

Available at http://www.biomedcentral.com/1471-2296/9/62

Middleton S, Griffiths R, Fernandez R, Smith B. Nursing Practice Environment: How does one Australian hospital compare with Magnet Hospitals? International Journal of Nursing Practice 2008; 15(5): 366-372.

Zwar N, Hermiz O, Hasan I, Comino E, Middleton S, Vagholkar S, Marks G. A cluster randomised controlled trial of nurse and GP partnership for care of Chronic Obstructive Pulmonary Disease. BMC Pulmonary Medicine 2008; 8: 8.

Hill K on behalf of the National Stroke Foundation Clinical Guidelines for Acute Stroke Management Expert Working Group (MiddletonS, member of Expert Working Group). Australian Clinical Guidelines for Acute Stroke Management 2007. International Journal of Stroke 2008; 3: 120-129.

Gattellari M, Worthington J, Zwar N, Middleton S. Barriers to the use of anticoagulation for non-valvular atrial fibrillation (NVAF): A representative survey of Australian Family Physicians. Stroke 2008; 39: 227-230.

Middleton S, Levi C, Dale S. Arrival time to stroke unit as crucial a measure as arrival time to emergency department. Stroke 2008; 39(1): 5. (Research letter)

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