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Mitochondria are typically thought of as the “powerhouses of the cell” as they produce the energy we use to function. It was recently discovered that Ergothioneine (EGT), a naturally occurring compound that is produced by fungi (e.g., mushrooms), increases the activity of a mitochondrial enzyme involved in energy production leading to improvements in running performance. Whether consuming EGT as a supplement has similar effects in humans is currently unknown.
The purpose of this study is to determine whether supplementation with 30 mg/day EGT for 2 weeks can increase the capacity of skeletal muscle to produce energy, leading to improvements in endurance performance. Given previous research has shown ET levels in the blood decline with age, we are targeting master’s cyclists (aged 35-50).
This study requires seven in-person visits to our Fitzroy laboratory
Total participation is ~14 hours over 3-4 weeks
• Personalised exercise testing results, including measurements of your body composition, and cardiovascular fitness (VO2peak).
• Gift card to cover any costs incurred with the appointment schedules and travel/parking
• Be aged 35 to 50 years old
• Routinely participate in cycling-based training (e.g., riding 150+ km/week, or currently engaged in structured riding with the intent to compete in events/Zwift etc.)
• Have a BMI 18.5-27 kg/m2
• Not diagnosed with diabetes, a heart condition or major chronic illness
• Willing to consume standardised meals and have blood and muscle sampled
Click here to read the Participant Information Letter and find out if you are eligible.
For more information please contact Jamie or Gennaro at MastersCycling@acu.edu.au
This study has been approved by the ACU Human Research Ethics Committee (2024-3543H).