Neuroscience of Addiction and Mental Health

Our program aims to map the clinical, cognitive and brain mechanisms of addiction, substance use behaviours, and related mental health problems (e.g., depression, anxiety, psychotic disorders). Addiction is highly prevalent and is the largest preventable contributor to burden of disease in the general community. We aim to map the factors that influence vulnerability, exacerbate harms and determine paths to recovery in addiction and related mental health disorders. To achieve our aims, we use next-generation multimodal brain imaging tools, carefully-controlled experimental designs and evidence-based behavioural and pharmacological interventions. We also investigate metrics to best measure and communicate exposure to substances to inform members of the community, clinical practitioners, public health experts and academics. Our research capitalises on established connections with unique and prestigious longitudinal global consortia and big data initiatives. The longer-term vision of this program is to identify targets for prevention and treatment of addiction and related harms.