Unit rationale, description and aim

Cardiovascular diseases have high prevalence and mortality in both Australia and throughout the world. It is imperative, therefore, that all health care professionals—including biomedical and exercise scientists, physiotherapists, and nutrition scientists—effectively advocate for a healthier lifestyle; promote a range of preventative measures; and manage, develop, and apply new treatment strategies for conditions. Success in these diverse roles, however, requires appreciation of the morphology and function of the cardiovascular system. The first module focusses on the molecular and cellular aspects of cardiac function, including the electrical properties of the heart, excitation-contraction coupling in cardiomyocytes, ECG, mechanical properties of cardiac tissue, and control of cardiac function. The second module is devoted to the discussion of the structure and function of the vascular system, including an overview of haemodynamics and the roles and specific features of the various elements of the vascular system. The third module discusses the main aspects of integrated cardiovascular regulation from local to systemic level, the main features of specific areas in the circulatory system (e.g., coronary, cerebral, pulmonary, and splanchnic circulation), and the most important cardiovascular changes accompanying physical exercise. When discussing cardiovascular function, this unit offers a clinically-oriented approach and links the delivered content to pathology, molecular medicine, and current biomedical research. This unit builds on previous units that offered the foundations of cardiovascular function with the aim to provide students with an advanced understanding of cardiovascular physiology.

2027 10

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Prerequisites

BIOL124 - Human Body in Health and Disease 1 or BIOL125 Human Biology 1

Learning outcomes

To successfully complete this unit you will be able to demonstrate you have achieved the learning outcomes (LO) detailed in the below table.

Each outcome is informed by a number of graduate capabilities (GC) to ensure your work in this, and every unit, is part of a larger goal of graduating from ACU with the attributes of insight, empathy, imagination and impact.

Explore the graduate capabilities.

Discuss the molecular and cellular basis of the un...

Learning Outcome 01

Discuss the molecular and cellular basis of the unique electrical and mechanical properties of the heart and explain how these properties are involved in cardiovascular regulation
Relevant Graduate Capabilities: GC1, GC7

Explain the gross and microscopic organisation as ...

Learning Outcome 02

Explain the gross and microscopic organisation as well as the specific, cellular- and molecular-level characteristics of the heart and blood vessels, and discuss the functional consequences of these features
Relevant Graduate Capabilities: GC1

Compare and contrast the main elements of local an...

Learning Outcome 03

Compare and contrast the main elements of local and systemic control of blood flow, explain their significance in maintaining homeostasis, and discuss pathologies associated with inadequate maintenance and/or control of blood flow
Relevant Graduate Capabilities: GC2, GC7, GC8

Explain the distinguishing features of coronary, c...

Learning Outcome 04

Explain the distinguishing features of coronary, cerebral, pulmonary, splanchnic, renal, cutaneous, and skeletal muscle circulation and discuss their contribution to the redistribution of circulation during physical exercise
Relevant Graduate Capabilities: GC2, GC7, GC8

Demonstrate ability to communicate cardiovascular ...

Learning Outcome 05

Demonstrate ability to communicate cardiovascular physiology-related information in both written and oral forms
Relevant Graduate Capabilities: GC2, GC8, GC12

Content

Topics will include:

  • Cardiac and smooth muscle—from molecules to organs
  • Electrical properties of and excitation contraction coupling in the heart
  • ECG—types of ECG recordings, the origin of ECG, and information that can be derived from ECG under physiological and pathological conditions
  • Homo- and heterometric regulation of the cardiac output
  • Haemodynamics, Hagen-Poiseuille law, Reynolds number, and vascular compliance
  • Components of the vascular tone and their significance in controlling blood flow and blood pressure
  • Cardiovascular reflexes (e.g., Bainbridge, Lovén, Goltz, Cushing, chemo- and baroreceptor reflex) and humoral regulation of circulation including the role of endothelium
  • Characteristics of coronary, cerebral, pulmonary, splanchnic, cutaneous, and skeletal muscle blood flow
  • Molecular aspects of cardiovascular adaptation during exercise

Assessment strategy and rationale

A range of assessment procedures is used to support achievement of the unit learning outcomes and the development of graduate attributes, consistent with the University's assessment requirements. The assessment tasks are designed to enable students to demonstrate achievement of each learning outcome. Ongoing formative assessment provides students with feedback on their progress and learning throughout the semester, while three summative assessments evaluate achievement of the unit learning outcomes. 

Assignment 1 is a quiz that assesses students’ knowledge and understanding of the learning material, together with their ability to apply concepts and think critically. 

Assignment 2 requires students to prepare a vodcast presentation. This assessment encourages students to synthesise and communicate their understanding of advanced physiological concepts, apply critical thinking, demonstrate creativity, and develop their oral communication skills while locating, evaluating, and effectively using scientific evidence. 

Assignment 3 is a supervised final examination that assesses students' comprehensive understanding of the learning material across the entire unit and their ability to integrate, analyse, and apply advanced physiological concepts to solve problems and communicate their responses effectively in writing. 

In order to pass this unit, students are required to achieve a final grade of 50% or more to demonstrate achievement of all learning outcomes. 

Overview of assessments

Quiz The quiz assesses students' knowledge ...

Quiz

The quiz assesses students' knowledge and understanding of the learning material, together with their critical thinking skills.

Weighting

25%

Learning Outcomes LO1, LO2, LO3, LO4
Graduate Capabilities GC1, GC2, GC7, GC8, GC12

Vodcast presentation The vodcast assessment task ...

Vodcast presentation

The vodcast assessment task encourages students to reflect on the learning material, utilize their advanced critical thinking skills, take advantage of their creativity, and showcase their oral communication skills as well as their ability to search, access, and critically evaluate scientific information.

Weighting

30%

Learning Outcomes LO3, LO5
Graduate Capabilities GC2, GC7, GC8, GC12

Final examination This task assesses st...

Final examination

This task assesses students' understanding, integration and application of the learning material from across the unit, together with their advanced critical thinking skills.

Weighting

45%

Learning Outcomes LO1, LO2, LO3, LO4, LO5
Graduate Capabilities GC1, GC2, GC7, GC8, GC12

Learning and teaching strategy and rationale

This unit is delivered via a combination of online and on-campus classes and uses active learning to help students understand the organisation and complex function of the cardiovascular system.

Students are provided with lectures, where their questions, active participation, and feedback are encouraged. Lectures aim at helping students acquire the fundamentals of the physiological functions, morphological basis, and significance of all major phenomena taught.

Students are also encouraged to attend and participate in weekly workshops, some of which will be scheduled on-campus to support the completion of assessment tasks. These workshops serve to both assimilate and apply the knowledge relevant to the given week’s topic learning objectives. The different types of learning activities provide opportunities for discussion of several challenging concepts, relating morphology to function, problem-based learning, case studies, group work, and peer learning. In short, workshops encourage and support students to review, recall, reinforce and assess key concepts.

Representative texts and references

Representative texts and references

Boron, W. F., & Boulpaep, E. L. (2026). Medical physiology (4th ed.). Elsevier. 

Hall, J.E., & Hall, M.E. (2026). Guyton and Hall textbook of medical physiology (15th ed). Elsevier.

Harris, D. M. (2023). Mohrman and Heller's cardiovascular physiology (10th ed.). McGraw Hill. 

Klabunde, R. E. (2021). Cardiovascular physiology concepts (3rd ed.). Wolters Kluwer. 

Pappano, A. J., & Wier, W. G. (2018). Cardiovascular physiology (11th ed.). Elsevier. 

Dirksen, R. T., Eisner, D. A., Ríos, E., & Sipido, K. R. (2022). Excitation–contraction coupling in cardiac, skeletal, and smooth muscle. Journal of General Physiology, 154(9), e202213244.  

Hafez, O. A., & Chang, R. B. (2025). Regulation of cardiac function by the autonomic nervous system. Physiology, 40(3), 258–270.  

Lasocka-Koriat, Z., Lewicka-Potocka, Z., Kaleta-Duss, A., Siekierzycka et al. (2024). Differences in cardiac adaptation to exercise in male and female athletes assessed by noninvasive techniques: a state-of-the-art review. American Journal of Physiology-Heart and Circulatory Physiology, 326(5), H1065–H1079.  

Martinez, M. W., Kim, J. H., Shah, A. B., Phelan, D. et al. E (2021). Exercise-induced cardiovascular adaptations and approach to exercise and cardiovascular disease: JACC state-of-the-art review. Journal of the American College of Cardiology, 78(14), 1453–1470.  

Suzuki, Y., Giles, W. R., Zamponi, G. W., Kondo, R., Imaizumi, Y., & Yamamura, H. (2024). Ca²⁺ signaling in vascular smooth muscle and endothelial cells in blood vessel remodeling: a review. Inflammation and Regeneration, 44, 50.   

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