Mapping and interrogating human exercise-regulated tissue and circulating biological networks

Published May 4, 2018


The health benefits of exercise in the prevention, delay and treatment of pathophysiology associated with metabolic disorders and ageing are widely appreciated. However, the breadth of molecular mechanisms underlying the systemic health benefits of exercise remain incompletely understood.  In response to exercise-induced metabolic and mechanical stress, biological networks are engaged in various cell types and organs throughout the body that involve protein post-translational modifications and changes in gene expression and metabolite profiles. This interdisciplinary research project will apply global, unbiased ‘omics-based technologies (e.g. proteomics, transcriptomics, metabolomics) to map the complexity and interconnection of tissue and circulating networks, focusing on mapping the time course of human skeletal muscle and plasma responses to different modes of exercise. This project involves several national and international collaborations and will help uncover a wealth of novel exercise-regulated biological mechanisms for future investigation in settings of health and disease.

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Dr Nolan Hoffman, ACU

Professor John Hawley, ACU

Marcus Callahan, ACU

Bridget Radford, ACU

Collaborating Institutions

University of Copenhagen

Novo Nordisk Foundation Center for Basic Metabolic Research

Edith Cowan University



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