Epigenetic control and the circadian clock: Turning back time on diabetes pathogenesis

Published May 4, 2018

This project involves an international network of researchers, led by the University of Copenhagen, with collaborators from Karolinska Institutet and University of California, Irvine. The aim is to further understand the health promoting effects of exercise in people with type 2 diabetes by determining the interaction between circadian rhythms and the metabolic response to exercise and nutrition. This will allow us to define potent, practical, time efficient use of fitness and nutrition that can be implemented to prevent insulin resistance and type 2 diabetes. We will take a “bench to bedside” approach and identify the time of day for optimal exercise-nutrient interventions to induce the greatest improvement of insulin sensitivity in people with type 2 diabetes.

Funding

Novo Nordisk Foundation Challenge Grant.

Duration

2015-2020

Investigators

Professor John Hawley, ACU

Professor Juleen Zierath, Karolinska Institute, Stockholm, Sweden

Professor Paulo Sassone-Corsi, University of Irvine, California, USA



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