Professor Liesbeth Vandenput

Senior researcher
Bone Health and Fractures Program

Liesbeth Vandenput

Areas of expertise: Osteoporosis, sex steroid metabolism, epidemiology, gut microbiota, fracture prediction

Phone: +613 9230 8056

Email: liesbeth.vandenput@acu.edu.au

Location: ACU Melbourne Campus

ORCID ID: 0000-0002-1712-6131 

Liesbeth Vandenput is a professor in the Bone Health and Fracture Research Program at the Mary MacKillop Institute for Health Research at Australian Catholic University (ACU). She is also affiliated with the Institute of Medicine at the University of Gothenburg, Sweden. After receiving her PhD in experimental bone research in Leuven at the KU Leuven, Belgium she moved to Gothenburg, Sweden in 2005 to gain experience in osteoporosis epidemiology. She focused on the importance of serum sex steroid levels in relation to bone traits and fracture risk in unique, well-characterized population-based cohorts. Other research topics included the genetics of bone and sex steroid levels using genome-wide association studies. Most recently, she investigates the impact of the gut microbiota on intestinal and local sex steroid levels.

She has received substantial external funding from the Swedish Research Council. She is also a member of the FRAX research group (University of Sheffield), led by professor John Kanis. She has made a significant contribution to the bone research field, with over 100 peer-reviewed publications and over 10,000 citations.

Select Publications

  • Vandenput L*, Kindblom JM*, Bygdell M, Nethander M, Ohlsson C (2019) Pubertal timing and adult fracture risk in men: A population-based cohort study. PLOS Med 16(12): e1002986
  • Colldén H, Landin A, Wallenius V, Elebring E, Fändriks L, Nilsson M, Ryberg H, Poutanen M, Sjögren K, Vandenput L, Ohlsson C (2019) The gut microbiota is a major regulator of androgen metabolism in intestinal contents. Am J Physiol Endocrinol Metab, doi: 10.1152/ajpendo.00338.2019
  • Ohlsson C, Nethander M, Karlsson MK, Rosengren BE, Ribom E, Mellström D, Vandenput L (2018) Serum DHEA and its sulfate are associated with incident fall risk in older men: the MrOS Sweden Study. J Bone Miner Res 33(7):1227-1232
  • Ohlsson C, Nethander M, Kindmark A, Ljunggren Ö, Lorentzon M, Rosengren BE, Karlsson MK, Mellström D, Vandenput L (2017) Low serum DHEAS predicts increased fracture risk in older men: the MrOS Sweden study. J Bone Miner Res 32(8):1607-1614
  • Vandenput L, Mellström D, Laughlin GA, Cawthon PM, Cauley JA, Hoffman AR, Karlsson MK, Rosengren BE, Ljunggren Ö, Nethander M, Eriksson AL, Lorentzon M, Leung J, Kwok T, Orwoll ES, Ohlsson C (2017) Low testosterone, but not estradiol, is associated with incident falls in older men: the international MrOS study. J Bone Miner Res 32(6):1174-1181
  • Nilsson ME*, Vandenput L*, Tivesten Å, Norlén A-K , Lagerquist MK, Windahl SH, Börjesson AE, Farman HH, Poutanen M, Benrick A, Maliqueo M, Stener-Victorin E, Ryberg H, Ohlsson C (2015) Measurement of a comprehensive sex steroid profile in rodent serum by high-sensitive gas chromatography-tandem mass spectrometry. Endocrinology 156(7):2492-2502
  • Ohlsson C, Nilsson ME, Tivesten Å, Ryberg H, Mellström D, Karlsson MK, Ljunggren Ö, Labrie F, Orwoll ES, Lee DM, Pye SR, O’Neill TW, Finn JD, Adams JE, Ward KA, Boonen S, Bartfai G, Casanueva FF, Forti G, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean MEJ, Pendleton N, Punab M, Vanderschueren D, Wu FCW, the EMAS Study Group, Vandenput L (2013) Comparisons of immunoassay and mass spectrometry measurements of serum estradiol levels and their influence on clinical association studies in men. J Clin Endocrinol Metab 98:E1097-E1102
  • Paternoster L, Lorentzon M, Lehtimäki T, Eriksson J, Kähönen M, Raitakari O, Laaksonen M, Sievänen H, Viikari J, Lyytikäinen L-P, Mellström D, Karlsson M, Ljunggren Ö, Grundberg E, Kemp JP, Sayers A, Nethander M, Evans DM*, Vandenput L*, Tobias JH*, Ohlsson C* (2013) Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure. PLoS Genet 9(2):e1003247
  • Ohlsson C, Wallaschofski H, Lunetta KL, Stolk L, Perry JRB, Koster A, Petersen A-K, Eriksson J, Lehtimäki T, Huhtaniemi IT, Hammond GL, Maggio M, Coviello AD, EMAS Study Group, Ferrucci L, Heier M, Hofman A, Holliday KL, Jansson J-O, Kähönen M, Karasik D, Karlsson MK, Kiel DP, Liu Y, Ljunggren Ö, Lorentzon M, Lyytikäinen L-P, Meitinger T, Mellström D, Melzer D, Miljkovic I, Nauck M, Nilsson M, Penninx B, Pye SR, Vasan RS, Reincke M, Rivadeneira F, Tajar A, Teumer A, Uitterlinden AG, Ulloor J, Viikari J, Völker U, Völzke H, Wichmann HE, Wu T-S, Zhuang WV, Ziv E, Wu FCW*, Raitakari O*, Eriksson A*, Bidlingmaier M*, Harris TB*, Murray A*, de Jong FH*, Murabito JM*, Bhasin S*, Vandenput L*, Haring R* (2011) Genetic determinants of serum testosterone concentrations in men. PLoS Genet 7(10):e1002313
  • Wang TJ, Zhang F, Richards JB, Kestenbaum B, van Meurs JB, Berry D, Kiel DP, Streeten EA, Ohlsson C, Koller DL, Peltonen L, Cooper JD, O'Reilly PF, Houston DK, Glazer NL, Vandenput L, Peacock M, Shi J, Rivadeneira F, McCarthy MI, Anneli P, de Boer IH, Mangino M, Kato B, Smyth DJ, Booth SL, Jacques PF, Burke GL, Goodarzi M, Cheung CL, Wolf M, Rice K, Goltzman D, Hidiroglou N, Ladouceur M, Wareham NJ, Hocking LJ, Hart D, Arden NK, Cooper C, Malik S, Fraser WD, Hartikainen AL, Zhai G, Macdonald HM, Forouhi NG, Loos RJ, Reid DM, Hakim A, Dennison E, Liu Y, Power C, Stevens HE, Jaana L, Vasan RS, Soranzo N, Bojunga J, Psaty BM, Lorentzon M, Foroud T, Harris TB, Hofman A, Jansson JO, Cauley JA, Uitterlinden AG, Gibson Q, Järvelin MR, Karasik D, Siscovick DS, Econs MJ, Kritchevsky SB, Florez JC, Todd JA, Dupuis J, Hyppönen E, Spector TD (2010) Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376:180-188
  • Vandenput L, Ohlsson C (2009) Estrogens as regulators of bone health in men. Nat Rev Endocrinol 5:437-443

Appointments and Affiliations

  • International Award for Publishing Excellence in the Journal of Clinical Endocrinology and Metabolism, 2014

International Journal Review Panel

  • Journal of Bone and Mineral Research, Journal of Clinical Endocrinology and Metabolism, Osteoporosis International, Journal of Steroid Biochemistry and Molecular Biology

Grant Agency Review Panels

  • Research Foundation - Flanders (FWO), Belgium

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