Professor Ego Seeman

Professor - Dept Medicine, Endocrinologist - Dept Endocrinology, Head - Metabolic Bone
Disease at Austin Health, University of Melbourne, Professorial Fellow, Mary MacKillop Institute for Health Research, Australian Catholic University.
Bone Health and Fractures Research Program

Areas of expertise: Epidemiology, Pathogenesis, Growth, Sex differences in growth, Study of risk factors for osteoporosis, Corticosteroid related osteoporosis, Ageing and bone loss, Treatment of osteoporosis, Osteoporosis and men.

Email: Ego.Seeman@acu.edu.au

Location: ACU Melbourne Campus

ORCID ID: 0000-0002-9692-048X

Professor Ego Seeman has worked in the field of osteoporosis for 35 years studying the epidemiology, pathogenesis and treatment of fragility fractures in women and men of Caucasian and Asian origin. He signalled that fractures in men is a public health problem, emphasised the role of growth as a forerunner of bone frailty in old age and emphasized the neglected role of cortical porosity as a cause of bone fragility. Professor Seeman has contributed to studies of many drugs used today. He has over 350 publications. He is past President of the Australian and New Zealand Bone Mineral Society, Editor of Progress in Osteoporosis, and an Associate Editor of Osteoporosis International.

Professor Seeman is one of three Professorial Fellows in the Bone Health and Fractures Research Program, forming an integral part of our collaborative research program entitled ‘Closing the Gap in Fracture Risk Assessment and Management’. The Professorial Fellows’ expertise in the clinical research of osteoporosis underpins the individual projects that together form MMIHR’s program of musculoskeletal research.

Ego is an Australian clinician with an excellent knowledge of clinical practice guidelines and relevancy in the Australian context. Together with his expertise in bone structure imaging, he provides alternative critical assessment of our project goals and assists with translating relevant findings to policy and clinical practice guidelines in Australia. This is particularly relevant to our project that aims to identify health and community services that are associated with a more rapid recovery of quality of life following fracture.

He has demonstrated a keen interest in fostering excellence across the Institute, with a focus on critical thinking and continual improvement. He has generously devoted his time to early career researcher and PhD candidates, becoming the Program’s most active ECR mentor and helping to support clinical research at the Institute in order to ensure that it is conducted at a level consistent with the highest world standards.

Select Publications

2019

  • Seeman E Martin TJ. Antiresorptive and anabolic agents in the prevention and reversal of bone fragility. Nature Reviews Rheumatology. In press. DOI 10.1038/s41584-01900172-3
  • Uliano S, Seeman E et al "Fat From Dairy Foods and ‘Meat’ Consumed. Within Recommended Levels is Associated with Favorable Serum Cholesterol Levels in Institutionalised Older Adults. J Nutritional Science. In press.
  • Zebaze R, Osima M, Seeman E et al. Adding Marrow Adiposity and Cortical Porosity to Femoral Neck Areal Bone Mineral Density Improves the Discrimination of Women with Nonvertebral Fractures from Controls. JBMR DOI 10.1002/jbmr. 3721
  • Parker L, Lin X, Garnham A, McConell G, Stepto NK, Hare DL, Byrnes E, Ebeling PR, Seeman E, Brennan-Speranza TC, Levinger I Glucocorticoid-Induced Insulin Resistance in Men Is Associated With Suppressed Undercarboxylated Osteocalcin J Bone Miner Res 2019;34:49-58
  • Zebaze, R. , Atkinson, E. J., Peng, Y. , Bui, M. , Ghasem‐Zadeh, A. , Khosla, S. and Seeman, E. (2019), Increased Cortical Porosity and Reduced Trabecular Density Are Not Necessarily Synonymous With Bone Loss and Microstructural Deterioration. JBMR Plus, 3: e10078. doi:10.1002/jbm4.10078
  • Barker AL, Soh SE, Sanders K, Pasco JA, Khosla S, Seeman E, McNeil JJ Aspirin and fracture risk: a systematic review and meta-analysis. BMJ open in press 2019;0:e026876. doi:10.1136/ bmjopen-2018-026876
  • Tatangelo, G, Sanders K, Seeman E et al The cost of osteoporosis, osteopenia and associated fractures in Australia in 2017. http://dx.doi.org/10.1002/jbmr.3640 JBMR 2019; 34
  • Smith C , Voisin S, Al Saedi A, Seeman E et al. Osteocalcin and its forms across the lifespan in adult men Bone 2019; https://doi.org/10.1016/j.bone.2019.115085

Accolades and awards

  • 2002 Fred C. Bartter Award from the American Society of Bone Mineral Research. Only 7 investigators outside the USA have received this career award during its 24 years existence.
  • 2004 University of Melbourne Matheson Lecturer 2004
  • 2008 Austin Hospital Medical Research Foundation Distinguished Scientist Award
  • 2009 International Osteoporosis Foundation Medal of Achievement for Outstanding Investigation in Osteoporosis Research.
  • 2013 J Haddad Jnr Award. International Bone Mineral Society for outstanding contributions to clinical research leading to understanding of physiology and disease and to changes in disease management and prevention.
  • 2014 Inaugural ANZBMS Career Achievement Award recognizing outstanding and major scientific or clinical contributions, and excellence in teaching and service to and within the bone and mineral field. 
  • 2016 Member of the Order of Australia. For significant service to medicine, as a researcher in the fields of osteoporosis and endocrinology, and as a clinician and academic.

International Journal review panels

Editorial roles

  • Editor, Advances in Osteoporosis 1993-1999, Progress in Osteoporosis 2000- continuing
  • Co Editor-in-Chief, Bonekey 2001-2011
  • Associate Editor Osteoporosis International 2006-current
  • Editorial Board – all main bone journals

Grant Agency review panels

Reviewer Journals

  • J Bone Mineral Res, Med J Australia, J Royal Australasian College Physicians, Osteoporosis International, Bone, Calcified Tissue International, Clin Exp Pharmacology and Physiology, J Clinical Invest, New Eng J Medicine, J Clin Endocrinol Metab, Nephrology.

Reviewer Granting Bodies

  • NHMRC, NHMRC Public Health Grants, Anticancer Council of Victoria, National Heart Foundation, Arthritis Society, Sandoz Foundation of Gerontological Research, Dairy Research Development Council, Ramaciotti.

Public Engagement

Editorial Board Member

  • Osteoporosis International 1993-continuing, Bone 1995-continuing, J Bone Min Research 1996-continuing, J Clin Endocrinol Metab 2001-2005, Calcif Tissue International 2001-2005.

Membership to Societies

  • Australian and New Zealand Society for Bone and Mineral Research
  • American Society for Bone and Mineral Research
  • Royal Australasian College of Physicians

Recent Committees

  • President Australian and New Zealand Bone Mineral Society 2004-6
  • Board member, International Osteoporosis Federation 1999-, re-elected 2002 and 2006 continuing
  • Board member IBMS 2002- 2006
    Scientific Program Committee Amer Soc Bone Min Research meeting 1993, 1996, 1998, 2000, 2002, 2006, 2009

Medical Advisor/Consultant for Industry

Australia and International MSD, Roche Products, Sanofi-Aventis, Serviere, Novaritis, Amgen, Eli Lilly. 

Personal research website

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